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, Myogyeong Cho Department of smart food & drug, Inje University , Gimhae , Korea Search for other works by this author on: Oxford Academic Harin Park Department of Digital Anti-aging Healthcare, Inje University , Gimhae , Korea Search for other works by this author on: Oxford Academic Sang Hyun Lee Department of smart food & drug, Inje University , Gimhae , Korea Department of Food Technology and Nutrition, Inje University , Gimhae , Korea Search for other works by this author on: Oxford Academic Myojeong Kim Department of smart food & drug, Inje University , Gimhae , Korea Department of Digital Anti-aging Healthcare, Inje University , Gimhae , Korea Search for other works by this author on: Oxford Academic Miran Jang Department of smart food & drug, Inje University , Gimhae , Korea Department of Food Technology and Nutrition, Inje University , Gimhae , Korea Corresponding Author: Miran Jang, Address: Department of Food Technology and Nutrition, Inje University, 197 Inje-ro, Gimhae-si, Gyeongsangnam-do, Korea (50834), Tel: +82-55-320-3234; E-mail: mrjang@inje.ac.kr Search for other works by this author on: Oxford Academic
https://orcid.org/0000-0002-6985-0957 Bioscience, Biotechnology, and Biochemistry, zbae043, https://doi.org/10.1093/bbb/zbae043
Published:
10 April 2024
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Myogyeong Cho, Harin Park, Sang Hyun Lee, Myojeong Kim, Miran Jang, Phyllodulcin from the hexane fraction of Hydrangea macrophylla inhibits glucose-induced lipid accumulation and reactive oxygen species (ROS) generation in Caenorhabditis elegans, Bioscience, Biotechnology, and Biochemistry, 2024;, zbae043, https://doi.org/10.1093/bbb/zbae043
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Abstract
We confirmed that the hexane layer of Hydrangea macrophylla leaf extract (HLH) is rich in phyllodulcin (PD), an alternative sweetener through HPLC analysis. To investigate in vivo activity of HLH and its PD, acute toxicity and growth rate of Caenorhabditis elegans were tested and there are no clinical abnormalities at 125-500μg/mL of HLH. HLH decreased the total lipid and TG contents dose-dependently glucose (GLU) induced obese worms. Also, HLH increased survival rates under oxidative and thermal stress and decreased body ROS contents significantly. Such antioxidant properties of HLH were attributed to the enhanced activity of the antioxidant enzyme catalase. To determine whether the effect of HLH was by PD, worms were treated with PD (concentration contained in HLH), and inhibitory effects on total lipids and ROS were observed. Our results suggest that HLH and its PD as a natural alternative sweetener can be material to improve metabolic diseases.
Graphical Abstract
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H. macrophylla and its phyllodulcin inhibit lipid and ROS accumulation in C. elegans fed a high-glucose diet.
Hydrangea macrophylla, phyllodulcin (PD), lipid accumulation, reactive oxygen species (ROS), Caenorhabditis elegans
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© The Author(s) 2024. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Subject
Food and Nutrition Science
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Regular Paper
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